Potentially Life-threatening
Adverse Drug Reactions
Physical and psychological dependence; withdrawal syndrome; impairs psychomotor performance, more accident-prone; aggression (in predisposed individuals esp in combination with alcohol); sedation. Postural hypotension, tachycardia, conduction disturbances. Dry mouth, wt gain, sour or metallic taste, stomatitis, constipation; blurring of vision, urinary retention, fatigue, dizziness, weakness, tremors, headache, confusion and delirium in elderly, sexual disturbances; peripheral neuropathy; urticaria, angioedema, sweating.
Adverse Drug Reactions
Chlordiazepoxide may rarely cause hypoplastic or haemolytic anaemia. Amitriptyline causes cardiac arrhythmias.
Interactions
Cimetidine increases serum conc of chlordiazepoxide. Absorption is impaired by Mg trisilicate, morphine, pethidine and atropine. Absorption enhanced by metoclopramide and aluminium hydroxide. Potentiates action of major neuroleptics.
